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Systemic inflammation response index is associated with increased all-cause and cardiovascular mortality in US adults with rheumatoid arthritis.
Wang, Wei; Yao, Wei; Tang, Wanyun; Li, Yuhao; Lv, Qiaomei; Ding, Wenbo.
Afiliação
  • Wang W; Department of Orthopedics, Dandong Central Hospital, China Medical University, Dandong, China.
  • Yao W; Department of Orthopedics, Dandong Central Hospital, China Medical University, Dandong, China.
  • Tang W; Department of Orthopedics, Dandong Central Hospital, China Medical University, Dandong, China.
  • Li Y; Department of Orthopedics, Dandong Central Hospital, China Medical University, Dandong, China.
  • Lv Q; Department of Rheumatology, Dandong Central Hospital, China Medical University, Dandong, China.
  • Ding W; Department of Orthopedics, Dandong Central Hospital, China Medical University, Dandong, China. Electronic address: dwb98003008@163.com.
Prev Med ; 185: 108055, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38925512
ABSTRACT

BACKGROUND:

Rheumatoid arthritis (RA) stands as a persistent systemic inflammatory autoimmune condition. Despite this understanding, the precise impact of the systemic inflammation response index (SIRI) on the prognosis of RA patients remains elusive. This study aims to elucidate the correlation between the inflammatory biomarker SIRI and both all-cause mortality and cardiovascular mortality among RA patients.

METHODS:

Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020, a retrospective analysis was conducted. Survival data were depicted through Kaplan-Meier survival curves, while the relationship between SIRI and all-cause or cardiovascular mortality in RA patients was scrutinized via multivariable Cox proportional hazards regression analysis and restricted cubic spline plots. Furthermore, subgroup analysis and mediation analysis were also performed.

RESULTS:

This study encompassed 2656 RA patients with a comprehensive 20-year follow-up, during which 935 all-cause deaths and 273 deaths attributed to cardiovascular disease were recorded. We observed a nonlinear positive correlation between SIRI with both all-cause and cardiovascular mortality in RA patients. Notably, at a SIRI level of 1.12, the hazard ratio reached 1, indicating a shift from low to high mortality risk. Furthermore, mediation analysis revealed that 12.6% of the association between RA and mortality risk was mediated through SIRI. Subgroup analysis indicated a more pronounced association between SIRI and mortality in female patients or those with a high BMI.

CONCLUSION:

This study underscores a non-linear positive correlation between the biomarker SIRI and both all-cause mortality and cardiovascular mortality in RA patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Cardiovasculares / Inquéritos Nutricionais / Inflamação Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Prev Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Cardiovasculares / Inquéritos Nutricionais / Inflamação Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Prev Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China