Versatile JMJD proteins: juggling histones and much more.
Trends Biochem Sci
; 2024 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-38926050
ABSTRACT
Jumonji C domain-containing (JMJD) proteins are found in bacteria, fungi, animals, and plants. They belong to the 2-oxoglutarate-dependent oxygenase superfamily and are endowed with various enzymatic activities, including demethylation of histones and hydroxylation of non-histone proteins. Many JMJD proteins are involved in the epigenetic control of gene expression, yet they also modulate a myriad other cellular processes. In this review we focus on the 33 human JMJD proteins and their established and controversial catalytic properties, survey their epigenetic and non-epigenetic functions, emphasize their contribution to sex-specific disease differences, and highlight how they sense metabolic changes. All this underlines not only their key roles in development and homeostasis, but also that JMJD proteins are destined to become drug targets in multiple diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2024
Tipo de documento:
Article