Synaptic architecture of leg and wing premotor control networks in Drosophila.
Nature
; 631(8020): 369-377, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38926579
ABSTRACT
Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles1. MN activity is coordinated by complex premotor networks that facilitate the contribution of individual muscles to many different behaviours2-6. Here we use connectomics7 to analyse the wiring logic of premotor circuits controlling the Drosophila leg and wing. We find that both premotor networks cluster into modules that link MNs innervating muscles with related functions. Within most leg motor modules, the synaptic weights of each premotor neuron are proportional to the size of their target MNs, establishing a circuit basis for hierarchical MN recruitment. By contrast, wing premotor networks lack proportional synaptic connectivity, which may enable more flexible recruitment of wing steering muscles. Through comparison of the architecture of distinct motor control systems within the same animal, we identify common principles of premotor network organization and specializations that reflect the unique biomechanical constraints and evolutionary origins of leg and wing motor control.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Asas de Animais
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Drosophila melanogaster
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Extremidades
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Neurônios Motores
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos