Quality of life for patients with advanced gastrointestinal cancer randomised to early specialised home-based palliative care: the ALLAN trial.
Br J Cancer
; 131(4): 729-736, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38951699
ABSTRACT
BACKGROUND:
The primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.METHODS:
We randomly assigned ambulatory patients with advanced GI cancer to early integration of SPC and palliative tumour-specific treatment or tumour-specific treatment alone. The primary endpoint was QoL assessed at baseline and every sixth week using the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire.RESULTS:
A total of 118 patients were randomised. The difference in total FACT-G score between patients assigned to early integration with SPC and controls was 5.2 points (95% CI -0.1 to 10.5, p = 0.216), 6.7 points (95% CI 0.2 to 13.3, p = 0.172), and 13 points (95% CI 5.7 to 20.2, p = 0.004) at weeks 6, 12, and 24, respectively.CONCLUSIONS:
This prospective randomised trial strengthens the argument for early integration of SPC with tumour-specific treatment in patients with advanced GI cancers. We found an improved QoL for patients with advanced GI cancer 24 weeks after randomisation to early integration of home-based SPC. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov (ref NCT02246725).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cuidados Paliativos
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Qualidade de Vida
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Neoplasias Gastrointestinais
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Serviços de Assistência Domiciliar
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suécia