Crystal structure of the cytotoxic macrocyclic trichothecene Isororidin A.
Acta Crystallogr C Struct Chem
; 80(Pt 8): 407-411, 2024 08 01.
Article
em En
| MEDLINE
| ID: mdl-38984909
ABSTRACT
The highly cytotoxic macrocyclic trichothecene Isororidin A (C29H40O9) was isolated from the fungus Myrothesium verrucaria endophytic on the wild medicinal plant `Datura' (Datura stramonium L.) and was characterized by one- (1D) and two-dimensional (2D) NMR spectroscopy. The three-dimensional structure of Isororidin A has been confirmed by X-ray crystallography at 0.81â
Å resolution from crystals grown in the orthorhombic space group P212121, with one molecule per asymmetric unit. Isororidin A is the epimer of previously described (by X-ray crystallography) Roridin A at position C-13' of the macrocyclic ring.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tricotecenos
Idioma:
En
Revista:
Acta Crystallogr C Struct Chem
/
Acta Crystallogr. C. Struct. Chem
/
Acta crystallographica. Section C, Structural chemistry. (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Grécia