MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses.
Nat Microbiol
; 9(10): 2626-2641, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39009691
ABSTRACT
Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic acid on host glycans as receptor, whereas some bat IAV require MHC class II complexes for cell entry. It is unknown how this difference evolved and whether dual receptor specificity is possible. Here we show that human H2N2 IAV and related avian H2N2 possess dual receptor specificity in cell lines and primary human airway cultures. Using sialylation-deficient cells, we reveal that entry via MHC class II is independent of sialic acid. We find that MHC class II from humans, pigs, ducks, swans and chickens but not bats can mediate H2 IAV entry and that this is conserved in Eurasian avian H2. Our results demonstrate that IAV can possess dual receptor specificity for sialic acid and MHC class II, and suggest a role for MHC class II-dependent entry in zoonotic IAV infections.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Antígenos de Histocompatibilidade Classe II
/
Ácido N-Acetilneuramínico
/
Influenza Humana
/
Vírus da Influenza A Subtipo H2N2
/
Internalização do Vírus
/
Influenza Aviária
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Microbiol
/
Nat. microbiol
/
Nature microbiology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suíça