Correlation between serum sex hormone-binding globulin levels and nutrition indicators and malnutrition exposure risk in men and postmenopausal women with type 2 diabetes.
BMC Endocr Disord
; 24(1): 117, 2024 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-39020340
ABSTRACT
BACKGROUND:
This study sought to investigate the correlation between serum sex hormone-binding globulin (SHBG) levels and nutrition indicators and the malnutrition exposure risk in men and postmenopausal women with type 2 diabetes mellitus (T2DM).METHODS:
A cross-sectional analysis was conducted, involving patients diagnosed with T2DM at the Guangdong Provincial People's Hospital between May 2018 and December 2019.RESULTS:
The study comprised 551 participants (363 men, mean age of 55.55 ± 11.57 years), among whom 167 (30.31%) were classified as with malnutrition exposure risk (GNRI ≤ 98). Multivariable logistic regression analysis revealed that SHBG (OR = 1.04, 95% CI 1.02-1.05, P < 0.001), glycated hemoglobin (OR = 1.36, 95% CI 1.22-1.51, P < 0.001), hemoglobin (OR = 0.96, 95% CI 0.94-0.97, P < 0.001), and non-alcoholic fatty liver disease (OR = 0.41, 95% CI 0.23-0.73, P < 0.003) were independently associated with the malnutrition exposure risk. SHBG was inversely correlated with body mass index (males r = -0.34; postmenopausal females r = -0.22), albumin (males r = -0.30; postmenopausal females r = -0.20), transferrin (males r = -0.28; postmenopausal females r = -0.19), and prealbumin (males r = -0.35; postmenopausal females r = -0.30) (all P < 0.05).CONCLUSIONS:
Serum SHBG levels are correlated with nutritional indicators and the risk of malnutrition in men and postmenopausal women with T2DM. A multicenter prospective study is imperative to verify this result in the future.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Globulina de Ligação a Hormônio Sexual
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Pós-Menopausa
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Desnutrição
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Diabetes Mellitus Tipo 2
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMC Endocr Disord
Ano de publicação:
2024
Tipo de documento:
Article