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Precise hourly personalized embryo transfer significantly improves clinical outcomes in patients with repeated implantation failure.
Xu, Yameng; Du, Jing; Zou, Yangyun; Lin, Xiaoli; Chen, Yulin; Ma, Lan; Jiang, Shan; Lin, Xiufeng.
Afiliação
  • Xu Y; Reproductive Medicine Centre, Boai Hospital of Zhongshan Affiliated with Southern Medical University, Zhongshan, China.
  • Du J; Reproductive Medicine Centre, Boai Hospital of Zhongshan Affiliated with Southern Medical University, Zhongshan, China.
  • Zou Y; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
  • Lin X; Department of Clinical Research, Yikon Genomics Company, Ltd., Suzhou, Jiangsu, China.
  • Chen Y; Reproductive Medicine Centre, Boai Hospital of Zhongshan Affiliated with Southern Medical University, Zhongshan, China.
  • Ma L; Department of Clinical Research, Yikon Genomics Company, Ltd., Suzhou, Jiangsu, China.
  • Jiang S; Reproductive Medicine Centre, Boai Hospital of Zhongshan Affiliated with Southern Medical University, Zhongshan, China.
  • Lin X; Reproductive Medicine Centre, Boai Hospital of Zhongshan Affiliated with Southern Medical University, Zhongshan, China.
Front Endocrinol (Lausanne) ; 15: 1408398, 2024.
Article em En | MEDLINE | ID: mdl-39076516
ABSTRACT

Purpose:

This study investigated whether RNA-Seq-based endometrial receptivity test (rsERT)-which provides precision for the optimal hour of the window of implantation (WOI)-can improve clinical outcomes of frozen embryo transfer (FET) cycles in patients with a history of repeated implantation failure (RIF).

Methods:

Patients with a history of RIF who received at least one autologous high-quality blastocyst during the subsequent FET cycle were retrospectively enrolled and divided into two groups rsERT and FET, comprising patients who underwent rsERT-guided pET (n=115) and standard FET without rsERT (n=272), respectively.

Results:

In the rsERT group, 39.1% (45/115) of patients were receptive. rsERT patients showed a higher probability of achieving both positive human chorionic gonadotropin (63.5% vs. 51.5%, P=0.03) and clinical pregnancy (54.8% vs. 38.6%, P=0.003) rates. In subgroup analysis, rsERT patients with non-receptive results had higher clinical pregnancy rates than patients undergoing FET (58.6% vs. 38.6%, P=0.003). rsERT patients with receptive results guided by rsERT with a precise WOI time had higher, although non-significant, clinical pregnancy rates (48.9% vs. 38.6%, P=0.192) than patients who underwent standard-time FET.

Conclusion:

Hourly precise rsERT can significantly improve the probability of achieving clinical pregnancy in patients with RIF, especially in those with non-receptive rsERT results.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Implantação do Embrião / Taxa de Gravidez / Transferência Embrionária Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Front Endocrinol (Lausanne) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Implantação do Embrião / Taxa de Gravidez / Transferência Embrionária Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Front Endocrinol (Lausanne) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China