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Association between metabolic syndrome and white matter integrity in young and mid-age post-9/11 adult Veterans.
Van Etten, Emily J; Knoff, Aubrey A; Colaizzi, Tristan A; Knight, Arielle R; Milberg, William P; Fortier, Catherine B; Leritz, Elizabeth C; Salat, David H.
Afiliação
  • Van Etten EJ; Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, Boston, MA 02130, United States.
  • Knoff AA; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States.
  • Colaizzi TA; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, United States.
  • Knight AR; Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, Boston, MA 02130, United States.
  • Milberg WP; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States.
  • Fortier CB; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, United States.
  • Leritz EC; Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, Boston, MA 02130, United States.
  • Salat DH; Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, Boston, MA 02130, United States.
Cereb Cortex ; 34(8)2024 Aug 01.
Article em En | MEDLINE | ID: mdl-39152671
ABSTRACT
Metabolic syndrome has been associated with reduced brain white matter integrity in older individuals. However, less is known about how metabolic syndrome might impact white matter integrity in younger populations. This study examined metabolic syndrome-related global and regional white matter integrity differences in a sample of 537 post-9/11 Veterans. Metabolic syndrome was defined as ≥3 factors of increased waist circumference, hypertriglyceridemia, low high-density lipoprotein cholesterol, hypertension, and high fasting glucose. T1 and diffusion weighted 3 T MRI scans were processed using the FreeSurfer image analysis suite and FSL Diffusion Toolbox. Atlas-based regions of interest were determined from a combination of the Johns Hopkins University atlas and a Tract-Based Spatial Statistics-based FreeSurfer WMPARC white matter skeleton atlas. Analyses revealed individuals with metabolic syndrome (n = 132) had significantly lower global fractional anisotropy than those without metabolic syndrome (n = 405), and lower high-density lipoprotein cholesterol levels was the only metabolic syndrome factor significantly related to lower global fractional anisotropy levels. Lobe-specific analyses revealed individuals with metabolic syndrome had decreased fractional anisotropy in frontal white matter regions compared with those without metabolic syndrome. These findings indicate metabolic syndrome is prevalent in this sample of younger Veterans and is related to reduced frontal white matter integrity. Early intervention for metabolic syndrome may help alleviate adverse metabolic syndrome-related brain and cognitive effects with age.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Veteranos / Síndrome Metabólica / Substância Branca Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Veteranos / Síndrome Metabólica / Substância Branca Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos