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Immune profiling of premalignant lesions in patients with Peutz-Jeghers syndrome.
Liu, Zhongyue; Wu, Boda; Shi, Xiaoliu; Zhou, Junfeng; Huang, Hui; Li, Zhihong; Yang, Mei.
Afiliação
  • Liu Z; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Wu B; Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Shi X; Department of Gastroenterology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
  • Zhou J; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Huang H; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Li Z; Endoscopic Medical Center, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Yang M; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article em En | MEDLINE | ID: mdl-39174496
ABSTRACT

BACKGROUND:

Peutz-Jeghers syndrome (PJS), is a rare autosomal dominant hereditary disease characterized by an elevated risk of various cancers. Serine/Threonine Kinase 11 (STK11) gene is a major tumor suppressor crucial for immune evasion with and beyond tumorigenic cells. It has garnered increasing attention in the realm of oncology treatment, particularly in the context of immunotherapy development.

OBJECTIVE:

This study aimed to assess the suitability of polyps obtained from individuals with PJS, resulting from germline STK11 deficiency, for immunotherapy. Additionally, we seek to identify potential shared mechanisms related to immune evasion between PJS polyps and cancers. To achieve this, we examined PJS polyps alongside familial adenomatous polyposis (FAP) and sporadic polyps.

METHODS:

Polyps were compared among themselves and with either the paracancerous tissues or colon cancers. Pathological and gene expression profiling approaches were employed to characterize infiltrating immune cells and assess the expression of immune checkpoint genes.

RESULTS:

Our findings revealed that PJS polyps exhibited a closer resemblance to cancer tissues than other polyps in terms of their immune microenvironment. Notably, PJS polyps displayed heightened expression of the immune checkpoint gene CD80 and an accumulation of myeloid cells, particularly myeloid-derived suppressor cells (MDSCs).

CONCLUSION:

The findings suggest an immunobiological foundation for the increased cancer susceptibility in PJS patients, paving the way for potential immune therapy applications in this population. Furthermore, utilizing PJS as a model may facilitate the exploration of immune evasion mechanisms, benefiting both PJS and cancer patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: United European Gastroenterol J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: United European Gastroenterol J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China