Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
J Exp Med
; 161(2): 429-34, 1985 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-3919142
ABSTRACT
We have mapped the gene encoding the T cell differentiation antigen Leu-2/T8 to human chromosome 2 by hybridization of a Leu-2/T8 complementary DNA clone to DNA from a panel of mouse-human cell hybrids. In situ hybridization further localizes the gene to the 2p1 region in close proximity to the Ig kappa light chain gene. The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos 1-3
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Genes MHC da Classe II
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Cadeias kappa de Imunoglobulina
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Cadeias Leves de Imunoglobulina
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Antígenos de Superfície
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1985
Tipo de documento:
Article