Humans are unreliable models of mouse disease.

Kim, Brian S

Kim, Brian S.

Afiliação

Kim BS; Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Allen Discovery Center for Neuroimmu

Cell ; 187(18): 4814-4818, 2024 Sep 05.

Article em En | MEDLINE | ID: mdl-39241741

ABSTRACT

ABSTRACT

In defying conventional views that dismissed itch as trivial, I persisted in studying basophils and ILC2s in human skin and atopic dermatitis. My research on JAK inhibitors for itch ultimately led to FDA-approved drugs. This is my story of disregarding categories and definitions-a story about an unconventional path in science that emphasizes innovation over conformity.

Assuntos

Dermatite Atópica; Modelos Animais de Doenças; Prurido; Humanos; Animais; Camundongos; Dermatite Atópica/patologia; Dermatite Atópica/tratamento farmacológico; Dermatite Atópica/imunologia; História do Século XX; História do Século XXI; Basófilos/metabolismo; Inibidores de Janus Quinases/uso terapêutico; Inibidores de Janus Quinases/farmacologia; Pele/patologia; Pele/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prurido / Dermatite Atópica / Modelos Animais de Doenças Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2024 Tipo de documento: Article

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