Nimodipine has an inhibitory action on neurotransmitter release from human cerebral arteries.
J Cereb Blood Flow Metab
; 5(2): 338-42, 1985 Jun.
Article
em En
| MEDLINE
| ID: mdl-3988833
ABSTRACT
The effect of the dihydropyridine nimodipine was studied on the resting and K+-evoked release of [3H]acetylcholine (ACh) and [3H]5-hydroxytryptamine (5HT) from postmortem human cerebral arteries. Nimodipine, at a concentration of 30 microM, significantly reduced the K+-evoked release of [3H]ACh from anterior and middle cerebral arteries by 36 and 70%, respectively, and the K+-evoked release of [3H]5HT from basilar and middle cerebral arteries by 55 and 66%, respectively. The mode of action of nimodipine is interpreted in terms of a specific effect on the depolarisation-induced calcium current occurring in neuronal elements present in these preparations but absent from brain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilcolina
/
Serotonina
/
Artérias Cerebrais
/
Ácidos Nicotínicos
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
1985
Tipo de documento:
Article