Vitamin D metabolites and osteomalacia in the human Fanconi syndrome.
Proc Eur Dial Transplant Assoc Eur Ren Assoc
; 21: 756-60, 1985.
Article
em En
| MEDLINE
| ID: mdl-3991574
ABSTRACT
Experimental evidence suggests that renal 1 alpha-hydroxylase activity is impaired in Fanconi syndrome. We have evaluated plasma vitamin D metabolites in five patients with Fanconi syndrome, three of whom had metabolic bone disease; plasma 1,25(OH)2D3 was low in the three patients with bone disease, and normal in the two patients without a bone mineralisation defect. The data supports the hypothesis that renal 1 alpha-hydroxylase activity may be impaired in human Fanconi syndrome, and that altered vitamin D metabolism may contribute to the pathogenesis of metabolic bone disease in Fanconi syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteomalacia
/
Vitamina D
/
Síndrome de Fanconi
Limite:
Aged
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Idioma:
En
Revista:
Proc Eur Dial Transplant Assoc Eur Ren Assoc
Assunto da revista:
NEFROLOGIA
/
TRANSPLANTE
Ano de publicação:
1985
Tipo de documento:
Article