New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results.
J Med Chem
; 28(9): 1346-50, 1985 Sep.
Article
em En
| MEDLINE
| ID: mdl-4032435
ABSTRACT
Three chemical pathways were used for the synthesis of four new N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]- and N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N- or N'-nitrosoureas. These compounds are plasma metabolites of CNCC, a promising antineoplastic (2-chloroethyl)nitrosourea. Preliminary antitumor evaluation was performed against L1210 leukemia implanted intraperitoneally in mice. Among these compounds, two of them exhibited a greater antitumor activity compared to that of the parent mixture.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia L1210
/
Compostos de Nitrosoureia
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1985
Tipo de documento:
Article