Cephalothin Prophylaxis and valve replacement.
Ann Thorac Surg
; 23(4): 333-6, 1977 Apr.
Article
em En
| MEDLINE
| ID: mdl-403867
ABSTRACT
In a study of antibiotic prophylaxis in adults undergoing heart valve replacement, we found that a 2 gm dose of cephalothin given intraoperatively produced adequate antimicrobial activity in the bloodstream throughout the period of cardiopulmonary bypass. A dosage of 1 gm every four hours postoperatively did not lead to significant accumulation of the antibiotic. With prophylaxis restricted to the intraoperative and early postoperative period, adverse drug reactions and superinfections were not a problem. Further, no cases of prosthetic valvulitis were encountered.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Valva Aórtica
/
Complicações Pós-Operatórias
/
Próteses Valvulares Cardíacas
/
Cefalotina
/
Valva Mitral
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Thorac Surg
Ano de publicação:
1977
Tipo de documento:
Article