Metabolites of 1,2,3,4-tetrachlorobenzene in monkey urine.
J Toxicol Environ Health
; 15(5): 603-7, 1985.
Article
em En
| MEDLINE
| ID: mdl-4046067
ABSTRACT
[14C(U)]-Labeled 1,2,3,4-tetrachlorobenzene was administered orally to squirrel monkeys. Urine was collected from these animals, pooled and analyzed for metabolites by thin-layer chromatography, high-performance liquid chromatography, and gas chromatography-mass spectroscopy. N-Acetyl-s-(2,3,4,5-tetrachlorophenyl) cysteine was shown to be the major metabolite and accounted for 85% of the radioactivity found in urine. A minor metabolite was identified as 2,3,4,5-tetrachlorophenol. This study demonstrates for the first time that an N-acetyl cysteine conjugate has been isolated and identified as metabolite of a chlorinated benzene. This pattern of chlorobenzene metabolism is significantly different from the one obtained with the rat and rabbit, where tetrachlorophenols constitute the major metabolites.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clorobenzenos
Limite:
Animals
Idioma:
En
Revista:
J Toxicol Environ Health
Ano de publicação:
1985
Tipo de documento:
Article