Vanadate selectively inhibits the Ko+-activated Na+ efflux in squid axons.
Biochim Biophys Acta
; 551(1): 220-3, 1979 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-427151
ABSTRACT
The effects of internally applied 1 mM vanadate on the Na+ efflux in dialysed squid axons were found to depend on the presence of external K+. In K+-free artificial sea water, vanadate did not produce any change in the rate of Na+ efflux, whereas in the presence of 10 mM K+ the Na+ efflux was reduced to values even lower than those observed in the absence of K+ (inversion of the K+-free effect). In vanadate-poisoned axons, K+ and NH+4 at low concentrations activated Na+ efflux, but at high concentrations both cations were inhibitory. However, NH+4 was always a better activator and a poorer inhibitor than K+.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Sódio
/
Axônios
/
Vanádio
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1979
Tipo de documento:
Article