Liquid-solid chromatographic determination of 6-demethylgriseofulvin in urine.
J Pharm Sci
; 65(3): 441-3, 1976 Mar.
Article
em En
| MEDLINE
| ID: mdl-4603
ABSTRACT
A specific and quantitative liquid-solid chromatographic method for the determination of 6-demethylgriseofulvin in human urine is reported. The method consists of extraction into an organic solvent, addition of internal standard, and analysis by liquid-solid chromatography using a UV detector. Griseofulvin, if present, can be determined simultaneously. The sensitivity of the method is 6 mug/ml of urine. Total 6-demethylgrisefulvin is determined after hydrolysis of the glucuronide conjugate with glucuronidase-sulfatase enzyme solution. The method is well suited for the analysis of a large number of samples.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Griseofulvina
Limite:
Humans
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1976
Tipo de documento:
Article