Tyramine infusions in bipolar illness: behavioral effects and longitudinal changes in pressor sensitivity.
Am J Psychiatry
; 136(11): 1460-3, 1979 Nov.
Article
em En
| MEDLINE
| ID: mdl-495801
ABSTRACT
Steady state intravenous tyramine dose pressor-response tests were administered to a patient with bipolar illness during depressed and hypomanic phases of her illness. The greatest tyramine sensitivity while unmedicated occurred when the patient was hypomanic, and the least sensitivity when she was depressed before her first switch. The data raise the possibility that changes in peripheral alpha-adrenergic receptor sensitivity accompany spontaneous mood cycles. Tyramine produced a replicable mood and cognitive alteration only in the infusion closest to the switch from hypomania to depression, suggesting that the CNS may be particularly susceptible to peripheral noradrenergic inputs at specific points in bipolar illness.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Pressão Sanguínea
/
Tiramina
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
1979
Tipo de documento:
Article