The nephrotoxicity of p-aminophenol. II. The effect of metabolic inhibitors and inducers.
Chem Biol Interact
; 27(2-3): 245-54, 1979 Oct.
Article
em En
| MEDLINE
| ID: mdl-498355
ABSTRACT
Inducers and inhibitors of the microsomal mixed function oxidase system have no consistent effect upon the nephrotoxicity of p-aminophenol, or on binding of the compound in vivo to cell protein. p-[ring-3H]Aminophenol was bound in vitro to kidney microsomal protein and to a lesser extent to liver. The binding was enhanced by preincubation of the p-aminophenol in air and inhibited by ascorbate, GSH, N2 and NADPH. These findings indicate that in contrast to paracetamol hepatoxicity which is dependent upon the mixed function oxidase system, that nephrotoxicity of p-aminophenol is dependent upon oxidation to a toxic metabolite by some other pathway. A similar metabolite may be responsible for the nephrotoxic action of phenacetin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Aminofenóis
/
Oxigenases de Função Mista
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Chem Biol Interact
Ano de publicação:
1979
Tipo de documento:
Article