Identification of S-(carboxymethyl)-L-cysteine and thiodiglycolic acid, urinary metabolites of 2,2'-bis-(chloroethyl)-ether in the rat.
Cancer Lett
; 7(5): 299-305, 1979 Sep.
Article
em En
| MEDLINE
| ID: mdl-509409
ABSTRACT
S-(carboxymethyl)-L-cysteine (CMC) and thiodiglycollic acid (TGA) were identified by gas chromatographic-mass spectrometric measurements in the urine of rats after intraperitoneal injections of 2,2'-bis-(chloroethyl)-ether (BCEE). It is therefore probable that BCEE is O-dealkylated by a mixed-function oxidation. The hepatocarcinogenic effect of BCEE may be explained by the liberation of chloroacetaldehyde in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tioglicolatos
/
Carbocisteína
/
Cisteína
/
Éter
/
Etil-Éteres
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1979
Tipo de documento:
Article