Effects of adenine nucleotide translocase inhibitors on dinitrophenol-induced Ca2+ efflux from pig heart mitochondria.
Biochim Biophys Acta
; 462(2): 403-13, 1977 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-588575
ABSTRACT
Bongkrekic acid and atractyloside, inhibitors of adenine nucleotide translocase, do not inhibit Ca2+ uptake and H+ production by pig heart mitochondria. However, bongkrekic acid, but not atractyloside, inhibits dinitrophenol-induced Ca2+ efflux and H+ uptake. Conversely, ruthenium red blocks Ca2+ uptake and H+ production but does not prevent dinitrophenol-induced Ca2+ efflux and H+ uptake by mitochondria. These results suggest that mitochondrial Ca2+ uptake and release exist as two independent pathways. The efflux of Ca2+ from mitochondria is mediated by a bongkrekic acid sensitive component which is apparently not identical to the ruthenium red sensitive Ca2+ uptake carrier.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atractilosídeo
/
Ácido Bongcréquico
/
Cálcio
/
Dinitrofenóis
/
Glicosídeos
/
Antibacterianos
/
Mitocôndrias Cardíacas
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1977
Tipo de documento:
Article