Inhibition of denaturation of human gamma globulin by a mixture of L-histidine, L-cystine, and copper, and its clinical implication in rheumatoid arthritis.
Arthritis Rheum
; 19(3): 593-601, 1976.
Article
em En
| MEDLINE
| ID: mdl-59600
ABSTRACT
A mixture of histidine, cystine, and copper mimicked gold thiomalate, N-ethylmaleimide, and p-chloro-mercuribenzoic acid in inhibiting sulfhydryl-disulfide interchange-mediated denaturation of human gamma globulin, bovine serum albumin, and diluted human serum. Measurable inhibitory effects were obtained with a mixture of physiologic concentrations of L-histidine, L-cystine, and copper. This work suggests a mechanism by which the hypohistidinemia of rheumatoid arthritis could contribute to the pathogenesis of the disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Desnaturação Proteica
/
Gama-Globulinas
/
Cobre
/
Cistina
/
Histidina
Limite:
Humans
Idioma:
En
Revista:
Arthritis Rheum
Ano de publicação:
1976
Tipo de documento:
Article