Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons.
Science
; 221(4615): 1054-7, 1983 Sep 09.
Article
em En
| MEDLINE
| ID: mdl-6136093
ABSTRACT
Prolonged treatment with classical antipsychotic drugs decreased the number of spontaneously active dopamine neurons in both the substantia nigra (A9) and the ventral tegmental area (A10) of the rat brain. In contrast, treatment with atypical antipsychotic drugs selectively decreased the number of A10 dopamine neurons. Related drugs lacking antipsychotic efficacy failed to decrease dopamine activity. These findings suggest that the inability of atypical antipsychotic drugs to decrease A9 dopamine neuronal activity may be related to their lower potential for causing tardive dyskinesia and that the inactivation of A10 neurons may be involved in the delayed onset of therapeutic effects during treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antipsicóticos
/
Ponte
/
Substância Negra
/
Dopamina
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article