Dopaminergic agonists: comparative actions of amine and sulfonium analogues of dopamine.
J Med Chem
; 27(5): 675-80, 1984 May.
Article
em En
| MEDLINE
| ID: mdl-6143827
ABSTRACT
We have investigated the possibility that structural modifications of the sulfonium analogue of dopamine (4) would produce the same pattern of biological activity as structural modifications of dopamine. A series of methyl- tetralinyl -, and naphthalenylsulfonium analogues 5-7 were prepared and tested for their ability to inhibit the potassium-evoked release of [3H]acetylcholine from striatal slices. All compounds were tested under normal conditions and after depletion of dopamine stores with reserpine and alpha-methyl-p-tyrosine. The amine and sulfonium analogues 2-6 all showed direct agonist activity. The sulfonium analogue 7 produced, predominantly, indirect activity. In contrast to the amine analogues, chemical modifications of the sulfonium compounds produced little change in their dopamine agonist activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dopamina
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1984
Tipo de documento:
Article