Serum and bone marrow radioimmunoassay of acid phosphatase in prostatic cancer.
Urology
; 19(1): 33-6, 1982 Jan.
Article
em En
| MEDLINE
| ID: mdl-6173949
ABSTRACT
Use of radioimmunoassay (RIA) for determinations of prostatic acid phosphatase has recently received considerable attention because of reported higher sensitivity and specificity than previous enzymatic assays. We have compared the sensitivity and specificity of a commercially available RIA to a highly specific enzymatic assay (thymolphthalein monophosphate) using 37 patients with prostatic cancer and 34 patients with surgically proved benign prostatic hyperplasia. Seventeen of the cancer patients and all 34 of the BPH patients were studied prospectively. We further evaluated specificity by performing the RIA on 25 specimens of bone marrow from patients with nonprostatic disease. Our results indicate the radioimmunoassay is not, at this time, an adequate screening tool, and we question its accuracy in staging patients anymore reliably than by enzymatic assay.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Fosfatase Ácida
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Medula Óssea
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Radioimunoensaio
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Técnicas Imunoenzimáticas
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Urology
Ano de publicação:
1982
Tipo de documento:
Article