Histamine release induced by neurotensin from rat peritoneal mast cells.
Eur J Pharmacol
; 76(2-3): 129-36, 1981 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-6174350
ABSTRACT
Neurotensin induced the release of histamine from both purified and non-purified rat peritoneal mast cells by a non-cytotoxic mechanism. It was effective at a concentration as low as 10(-8) M. The dose-response curve for the neurotensin effect was triphasic and initial gentle rise, a plateau (2.5 X 10(-7) -2.5 X 10(-6) M) and a second rise. Disodium cromoglycate markedly, but benzalkonium chloride only slightly, inhibited the neurotensin-induced release. The effect of neurotensin was markedly different from that of substance P, bradykinin and compound 48/80 with respect to both the dose-response curve and the sensitivity to benzalkonium chloride. These inducers of histamine release showed somewhat different effects with changes in pH and temperature. Their actions did not require extracellular Ca2+. The results indicate that neurotensin is a potent histamine releaser acting directly on mast cells. Its mode of action may be different from those of the other substances tested.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurotensina
/
Liberação de Histamina
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1981
Tipo de documento:
Article