Cerebrospinal fluid proteins and cells in normal-pressure hydrocephalus.
J Neurol
; 228(3): 171-80, 1982.
Article
em En
| MEDLINE
| ID: mdl-6186790
ABSTRACT
A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No characteristic changes could be found in the "CSF-specific" protein fraction. After the shunt operation 65% of the patients had a BBB dysfunction to macromolecules and 70% had two additional acidic protein bands in the CSF-specific fraction. Ventricular CSF protein content was 73% of lumbar CSF content when shunts were patent. Isotope encephalography showed a radionuclide accumulation at the intracranial part of the shunt system, indicating that the BBB damage might be located round the shunt catheter.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Líquido Cefalorraquidiano
/
Proteínas do Líquido Cefalorraquidiano
/
Hidrocefalia
/
Hidrocefalia de Pressão Normal
Limite:
Humans
Idioma:
En
Revista:
J Neurol
Ano de publicação:
1982
Tipo de documento:
Article