Chronic experimental allergic encephalomyelitis in guinea pigs: immunologic studies on the two major myelin proteins.
Cell Immunol
; 86(2): 567-74, 1984 Jul.
Article
em En
| MEDLINE
| ID: mdl-6203654
ABSTRACT
Humoral and cell-mediated immunity to the two major myelin proteins, basic protein (MBP) and proteolipid protein, have been investigated during the course of chronic experimental allergic encephalomyelitis (EAE) induced in guinea pigs with whole neural tissue. A positive proliferative response to MBP was observed at 10 and 13 days postimmunization, but was not detectable at subsequent stages. Serum antibodies to MBP first appeared during the chronic stages of the disease. A proliferative response to proteolipid apoprotein was not detected during any stage of chronic EAE. Guinea pigs immunized with proteolipid alone, however, showed a proliferative response. The data suggest that MBP is one of the antigens involved in the induction of the acute episode of chronic EAE, but its role in later stages and that of proteolipid protein remain unknown.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Proteolipídica de Mielina
/
Proteína Básica da Mielina
/
Encefalomielite Autoimune Experimental
/
Imunidade Celular
/
Formação de Anticorpos
Limite:
Animals
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
1984
Tipo de documento:
Article