Cytogenetic investigations on Werner's syndrome, Acrogeria and Keratosis Palmo-Plantaris.
J Genet Hum
; 31(3): 211-21, 1983 Sep.
Article
em En
| MEDLINE
| ID: mdl-6228640
ABSTRACT
The frequencies of sister chromatid exchanges and of aspecific chromosome aberrations have been investigated in the lymphocytes from a Werner patient, from an Acrogeria patient and from three members of a family with Keratosis Palmo-Plantaris. These investigations point out that 1) the SCE frequency is significatively enhanced in Werner as in KPP lymphocytes, 2) the frequency of aspecific chromosome aberrations is increased only in Werner lymphocytes, without evidence of variegated translocation mosaicism. The findings confirm that SCE and chromosome aberrations do not necessarily result from the same genetic damage and that SCE may represent the cytological evidence of unexcised non fatal DNA lesions, which occasionally may be responsible for carcinogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progéria
/
Síndrome de Werner
/
Ceratodermia Palmar e Plantar
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Genet Hum
Ano de publicação:
1983
Tipo de documento:
Article