Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer.
J Natl Cancer Inst
; 65(3): 529-34, 1980 Sep.
Article
em En
| MEDLINE
| ID: mdl-6251302
ABSTRACT
Sialyltransferase and 5'-nucleotidase were measured in the sera of 135 women with breast cancer 53 undergoing mastectomy for primary cancer and 83 receiving different modalities of palliative therapy for metastatic disease. The objective of this study was to determine whether these enzyme levels were associated with the extent of the disease and whether changes in these enzyme levels could be correlated with success or failure of treatment. Mastectomy caused a rapid fall of elevated enzyme levels to within the normal range in all patients with stage I breast cancer but not in those with stage II or III disease. In women with metastatic disease, elevated enzyme levels fell only in patients responding to treatment. Thus serum sialyltransferase and 5'-nucleotidase activities are reliable biomarkers of breast cancer activity, and serial measurement of these enzyme activities provides a useful tool for the monitoring of disease activity and success or failure of the treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sialiltransferases
/
Transferases
/
Neoplasias da Mama
/
Nucleotidases
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1980
Tipo de documento:
Article