Intermediate filaments in eosinophilic cells of epithelioid sarcoma: a light-microscopic, ultrastructural, and electrophoretic study.
Am J Surg Pathol
; 5(2): 195-202, 1981 Mar.
Article
em En
| MEDLINE
| ID: mdl-6261597
ABSTRACT
A 41-year-old woman had a mass in her thigh for 5 months. The neoplasm had areas histologically typical of epithelioid sarcoma, but there were also cells with abundant eosinophilic, vacuolated cytoplasm and peripheral, distorted nuclei. These cells resembled signet-ring cells but contained no intracellular mucin. Rather, their cytoplasm was filled with large aggregates of 7-10 nm diameter, nonperiodic filaments, and lipid droplets. Lipid droplets and filaments are common in epithelioid sarcomas, but their presence in sufficient volume to displace the nucleus in a signet-ring fashion has not been described. Electrophoretic analysis of a tumor extract showed that actin was present in insufficient concentration (1-3%) to account for the filamentous aggregates. However, two proteins of 51,000 and 63,000 daltons apparent molecular weight comprised 40-50% of the total protein, suggesting that one or both were the major subunits of the abundant cytoplasmic filaments. Filaments of identical ultrastructural size have been described in a variety of human neoplasms and may be related to a filament characterized in other species and termed vimentin.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Coxa da Perna
/
Citoesqueleto
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Am J Surg Pathol
Ano de publicação:
1981
Tipo de documento:
Article