Aging and benzodiazepine binding in the rat cerebral cortex.
Life Sci
; 30(4): 343-6, 1982 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-6280005
ABSTRACT
The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fisher-344 rats. No age-related differences in the association, equilibrium, or dissociation, binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzodiazepinas
/
Envelhecimento
/
Córtex Cerebral
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1982
Tipo de documento:
Article