Effect of glucose-6-phosphate dehydrogenase deficiency on the benz(a)pyrene toxicity for in vitro cultured human skin fibroblasts.
Res Commun Chem Pathol Pharmacol
; 38(2): 301-11, 1982 Nov.
Article
em En
| MEDLINE
| ID: mdl-6298917
ABSTRACT
Human skin fibroblasts, isolated in vitro, from donors carrying the Mediterranean variant of glucose-6-phosphate dehydrogenase, exhibit a sharp decrease of hexose monophosphate shunt and NADPH/NADP+ ratio when compared to the fibroblasts from normal donors. This behavior is coupled to an increase of the resistance to cell death and growth inhibition induced by benz(a)pyrene, whose activation proceeds through the NADPH-dependent arene oxide formation. No differences were observed in the toxic effects of methylnitrosourea, a carcinogen that does not need metabolic activation, on normal and variant fibroblasts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzopirenos
/
Deficiência de Glucosefosfato Desidrogenase
Limite:
Humans
/
Male
Idioma:
En
Revista:
Res Commun Chem Pathol Pharmacol
Ano de publicação:
1982
Tipo de documento:
Article