Effect of 41-CRF antiserum on the secretion of ACTH, B-endorphin and alpha-MSH in the rat.
Peptides
; 4(3): 301-4, 1983.
Article
em En
| MEDLINE
| ID: mdl-6314292
ABSTRACT
In order to elucidate the physiological role of the 41 amino-acid residue corticotropin-releasing factor (41-CRF) on the secretion of ACTH, B-Endorphin and alpha-MSH, plasma levels of these peptides were measured by radioimmunoassay in intact and adrenalectomized rats, two hours after the injection of either 41-CRF antiserum (CRF-AS) or normal rabbit serum for controls. The administration of CRF-AS strikingly lowered the plasma ACTH levels in both intact and adrenalectomized rats. A statistically significant reduction of plasma levels of B-Endorphin was also observed in the same rats. However, the effect of CRF-AS on B-Endorphin release was less pronounced than the effect on ACTH release. No changes in plasma alpha-MSH levels were observed after passive immunization with CRF-AS. We conclude that, in the rat, 41-CRF plays a physiological role in the regulation of ACTH and B-Endorphin secretion, but is not involved in the regulation of alpha-MSH release from the pituitary gland.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Liberador da Corticotropina
/
Endorfinas
/
Hormônios Estimuladores de Melanócitos
/
Hormônio Adrenocorticotrópico
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
1983
Tipo de documento:
Article