Centrally administered N-terminal fragments of ACTH (1-10, 4-10, 4-9) display convulsant properties in rabbits.
Peptides
; 4(3): 315-8, 1983.
Article
em En
| MEDLINE
| ID: mdl-6314294
ABSTRACT
Electroencephalographic and behavioral effects of the following ACTH fragments 1-4, 4-9, 4-11, 1-10, 4-10, 1-13, 1-17 and 1-24 were studied in rabbits. Sequences 4-9, 1-10 and 4-10 displayed some epileptic properties, i.e., they induced epileptic seizures (only electrographic or also behavioral) or increased hippocampal spiking. The 4-9 sequence seemed to be the common sequence responsible for these proconvulsant effects. The possible involvement of the enkephalinergic system is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Hormônio Adrenocorticotrópico
/
Convulsivantes
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
1983
Tipo de documento:
Article