Effect of indomethacin on Epstein-Barr virus early antigen induction.
Cancer Res
; 44(3): 981-3, 1984 Mar.
Article
em En
| MEDLINE
| ID: mdl-6318991
ABSTRACT
The lymphoid cell line, Raji, was derived from a Burkitt's lymphoma and is readily inducible for Epstein-Barr virus (EBV) early antigen synthesis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Treatment of Raji and other EBV genome-positive cells with indomethacin caused a marked inhibition of early antigen induction by 12-O-tetradecanoylphorbol-13-acetate and other chemical inducers. However, this effect did not appear to be due to inhibition of prostaglandin synthesis since the concentration of indomethacin required to inhibit EBV-early antigen induction was 50- to 100-fold higher than that normally required for the inhibition of prostaglandin synthesis. In addition, no prostaglandin synthesis was detected in 12-O-tetradecanoylphorbol-13-acetate-treated Raji cells. EBV-early antigen induction by superinfection was resistant to inhibition by indomethacin and indicates that induction by chemical inducers and by super-infection follows different pathways. Indomethacin at the concentrations required to inhibit EBV-early antigen induction also was cytostatic, which indicates that the cell cycle phase may be an important factor in viral induction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Indometacina
/
Herpesvirus Humano 4
/
Antígenos Virais
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1984
Tipo de documento:
Article