Common region on chromosome 14 in T-cell leukemia and lymphoma.
Science
; 226(4681): 1445-7, 1984 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-6438800
ABSTRACT
Chromosome 14 breakpoints in malignant human lymphocytes cluster on the long (q) arm near bands q11 and q32. An inversion of chromosome 14 due to breaks in q11.2 and q32.3 has now been found in a newly established childhood T-cell lymphoma cell line and confirmed in T-cell chronic lymphocytic leukemia. A translocation was also found between chromosomes 10 and 14 with a breakpoint at 14q11.2 in another T-cell lymphoma cell line. It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function. Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T-cell malignancies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Linfoide
/
Aberrações Cromossômicas
/
Linfoma
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Science
Ano de publicação:
1984
Tipo de documento:
Article