Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.
Science
; 222(4620): 169-72, 1983 Oct 14.
Article
em En
| MEDLINE
| ID: mdl-6623064
ABSTRACT
Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rodaminas
/
Xantenos
/
Neoplasias da Bexiga Urinária
/
Carcinoma
/
Carcinoma de Ehrlich
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article