[Practical value of the selective precipitation of LDL, LDL-phospholipids and the molar ratio of cholesterol to LDL-phospholipids in lecithin-cholesterol-acyltransferase deficiency]. / Intérêt pratique de la précipitation sélective des LDL, LDL-phospholipides et rapport molaire cholestérol sur phospholipides des LDL (LDL-RMCP) dans les déficiences en lécithine-cholestérol-acyl-transférase.
Ann Biol Clin (Paris)
; 41(5): 311-4, 1983.
Article
em Fr
| MEDLINE
| ID: mdl-6666872
ABSTRACT
There is a high morbidity from hepato-biliary disease in France. These diseases are often accompanied by a reduction in serum lecithin-cholesterol-acyl-transferase activity, which is difficult and costly to diagnose in the laboratory. Thanks to a simple and inexpensive method of selective precipitation of light lipoproteins, we have been able to establish the practical value of the determination of the LDL-phospholipids and the molar cholesterol ratio on the phospholipids in the LDL (MCPR) in familial or secondary deficiencies of Lecithin-Cholesterol-Acyl-Transferase. These conditions are characterized by a high proportion of serum phospholipids transported by the LDL (more than 60%) and by the marked reduction in the cholesterol ratio of the phospholipids in the LDL. The authors propose a classification for the commonest causes of lecithin-cholesterol-acyl-transferase deficiency.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Colesterol
/
Hipolipoproteinemias
/
Deficiência da Lecitina Colesterol Aciltransferase
/
Lipoproteínas LDL
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
1983
Tipo de documento:
Article