Treatment of canine transmissible venereal tumor by intravenous administration of protein A.
J Biol Response Mod
; 3(3): 271-7, 1984.
Article
em En
| MEDLINE
| ID: mdl-6747669
ABSTRACT
To determine if protein A can induce tumoricidal effects, transmissible venereal tumor-bearing dogs were treated by intravenous protein A administration. Each dog in the experimental group was treated twice a week with protein A, 100 micrograms/kg body weight, for a total of 10 treatments. Control dogs were treated with a 0.9% sodium chloride solution. No decrease in tumor volume attributable to protein A treatment was observed. However, transient healing of ulcerated tumors was observed in two dogs in the protein A-treated group but not in any in the control group. Following the first inoculation of protein A, a significant transient increase in polymorphonuclear cells and a significant transient decrease in lymphocyte and monocyte counts was detected, with a return of the counts to pretreatment levels by 24 h after the last protein A treatment. Intravenous protein A administration also failed to induce tumor regression in a guinea pig and a murine tumor model. These results suggest that the antitumor effects observed in protein A immunoadsorption studies have not been induced by leakage of protein A into the circulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Estafilocócica A
/
Tumores Venéreos Veterinários
Limite:
Animals
Idioma:
En
Revista:
J Biol Response Mod
Ano de publicação:
1984
Tipo de documento:
Article