Rise of hepatic glutathione concentration induced in rats by chronic lead nitrate treatment. Its role in aflatoxin B1 intoxication.
Res Commun Chem Pathol Pharmacol
; 38(1): 97-112, 1982 Oct.
Article
em En
| MEDLINE
| ID: mdl-6815742
ABSTRACT
Liver concentration of the reduced form of glutathione is increased by chronic lead nitrate administration. Hepatic glutathione content is lowered by acute aflatoxin B1 intoxication while in lead-pretreated rats this decrement is not evident. The administration of lead nitrate which increases liver glutathione also decreases acute aflatoxin B1 toxicity. This provides additional evidence that, in the liver, glutathione concentration plays a role in controlling acute aflatoxin B1 toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aflatoxinas
/
Glutationa
/
Chumbo
/
Fígado
/
Nitratos
Limite:
Animals
Idioma:
En
Revista:
Res Commun Chem Pathol Pharmacol
Ano de publicação:
1982
Tipo de documento:
Article