Hysteresis in the force-calcium relation in muscle.
Science
; 219(4588): 1075-7, 1983 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-6823567
ABSTRACT
Calcium ions activate muscle contraction. The mechanism depends on the calcium sensitivity of the proteins that regulate contraction. Evidence is presented for the reverse phenomenon, where contraction modulates calcium sensitivity. Increasing the force level increased calcium sensitivity in intact fibers showing that the relation between force and calcium is not unique. A particular calcium concentration can maintain a higher force level than it can create. The results were confirmed in skinned fiber experiments. Transient reduction of the force led to a transient reduction in calcium binding, suggesting a simple mechanism for the hysteresis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Contração Muscular
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article