Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate.
Lipids
; 18(3): 267-9, 1983 Mar.
Article
em En
| MEDLINE
| ID: mdl-6855486
ABSTRACT
Thromboxane (TXB2) and malonaldehyde (MDA) production by thrombin-stimulated washed platelet were evaluated in rats fed 6 combinations of dietary vitamin E (0, 100, 1000 ppm) and linoleate (6.5 and 17.0 en%) for 23 weeks. The molar ratio of MDATXB2 was consistently near 3 in all groups studied. In animals receiving the lower linoleate diets, TXB2 and MDA synthesis were inversely related to the dietary vitamin E concentrations and the levels of MDA and TXB2 were positively correlated (r = 0.99) with decreasing vitamin E in the diet. High dietary linoleate (17.0 en%), independent of vitamin E status, reduces TXB2 and MDA synthesis. The importance of dietary antioxidant on platelet prostanoid synthesis is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Plaquetas
/
Ácidos Linoleicos
/
Tromboxanos
/
Malonatos
/
Malondialdeído
Limite:
Animals
Idioma:
En
Revista:
Lipids
Ano de publicação:
1983
Tipo de documento:
Article