Sulfation preceding deiodination of iodothyronines in rat hepatocytes.
Science
; 221(4605): 81-3, 1983 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-6857270
ABSTRACT
In man and animals iodothyronines are metabolized by deiodination and conjugation with glucuronic acid or sulfate. Until now these processes have been regarded as independent reactions. However, in the present study a close interaction of these pathways was observed in the hepatic metabolism of 3,3'-diiodothyronine and 3,3',5-triiodothyronine. Studies with rat hepatocytes and liver microsomes indicated that sulfation of the phenolic hydroxyl group facilitates the deiodination of these compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios Tireóideos
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article