Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes.

ABSTRACT

Transneuronal degeneration of retinal ganglion cells was directly demonstrated in a patient who had unilateral removal of the striate cortex forty years prior to necropsy. For comparison, another case is presented showing anterograde transneuronal atrophy forty years after enucleation of one eye.