The effect of ethanol administration on renal and hepatic mixed-function oxidases in the Fischer 344 rat.
Toxicol Lett
; 12(4): 265-71, 1982 Aug.
Article
em En
| MEDLINE
| ID: mdl-7135425
ABSTRACT
Administration of ethanol in the drinking water increases hepatic cytochrome P-450 content and xenobiotic metabolism. However, the effect on renal xenobiotic metabolism has not been investigated. Chronic consumption of ethanol (15% solution in the drinking water) increased hepatic cytochrome P-450 content as well as ethoxycoumarin-O-deethylase, aniline hydroxylase and benzphetamine-N-demethylase activities. No change in renal cytochrome P-450 was detected after chronic ethanol consumption whereas ethoxycoumarin-O-deethylase activity in renal microsomes was significantly increased.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Etanol
/
Oxigenases de Função Mista
/
Rim
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1982
Tipo de documento:
Article