The effect of ethanol administration on renal and hepatic mixed-function oxidases in the Fischer 344 rat.

ABSTRACT

Administration of ethanol in the drinking water increases hepatic cytochrome P-450 content and xenobiotic metabolism. However, the effect on renal xenobiotic metabolism has not been investigated. Chronic consumption of ethanol (15% solution in the drinking water) increased hepatic cytochrome P-450 content as well as ethoxycoumarin-O-deethylase, aniline hydroxylase and benzphetamine-N-demethylase activities. No change in renal cytochrome P-450 was detected after chronic ethanol consumption whereas ethoxycoumarin-O-deethylase activity in renal microsomes was significantly increased.