Treatment of severe lactic acidosis with dichloroacetate.
Diabetes Care
; 5(4): 391-4, 1982.
Article
em En
| MEDLINE
| ID: mdl-7151655
ABSTRACT
Four patients with severe lactic acidosis associated with septic shock were treated with sodium dichloroacetate (DCA) (50 mg/kg body wt), an activator of pyruvate dehydrogenase. All patients were in a group with an expected mortality rate of 90-100%, based on previous studies. In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later. Markedly elevated blood pyruvate and alanine levels also decreased to normal. After treatment, the arterial blood pH rose to 7.53, and vasopressor agents were no longer needed to support blood pressure. Some degree of biochemical improvement was also noted in the other cases in whom the blood lactate levels before treatment were 15, 17, and 31 mM. However, all three patients eventually died of refractory acidosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidose
/
Ácido Dicloroacético
/
Lactatos
/
Acetatos
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diabetes Care
Ano de publicação:
1982
Tipo de documento:
Article