Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.
J Exp Med
; 153(3): 694-705, 1981 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-7252411
ABSTRACT
The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Infecções Pneumocócicas
/
Colina
/
Anticorpos
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1981
Tipo de documento:
Article